Stenting of coronary arteries: Has a modern Pandora's box been opened?

Noninvasive ventilation: has Pandora’s box been opened?

Exacerbations of COPD are the largest single cause of hospital admission with respiratory disease, and are frequently associated with impaired gas exchange and mortality rates of up to 14%. 1 Acute hypercapnic respiratory failure leads to admissions to intensive care units with a mortality rate of 59% at one year. 2 Noninvasive ventilation (NIV) is a well established and validated therapy for a...

Coronary stenting: has the rubicon been crossed?

New insights in IBS-like disorders: Pandora's box has been opened; a review

The most complained gastrointestinal symptoms are chronic diarrhea, bloating and abdominal pain. Once malignancies and inflammatory bowel diseases are excluded, irritable bowel syndrome (IBS) and the so called "IBS-like disorders" should be taken into account. The relationship between IBS as defined by Rome IV criteria and these clinical conditions is sometimes obscure, since many IBS patients ...

Has evidence‐based medicine ever been modern? A Latour‐inspired understanding of a changing EBM

Evidence-based health care (EBHC), previously evidence-based medicine (EBM), is considered by many to have modernized health care and brought it from an authority-based past to a more rationalist, scientific grounding. But recent concerns and criticisms pose serious challenges and urge us to look at the fundamentals of a changing EBHC. In this paper, we present French philosopher Bruno Latour's...

Primary Stenting Versus Balloon Angioplasty in Occluded Coronary Arteries

Background—Balloon angioplasty (PTCA) of occluded coronary arteries is limited by high rates of restenosis and reocclusion. Although stenting improves results in anatomically simple occlusions, its effect on patency and clinical outcome in a broadly selected population with occluded coronary arteries is unknown. Methods and Results—Eighteen centers randomized 410 patients with nonacute native c...